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Porous Tip Sheathless CE-MS Interface
Moini proposed to etch the end of the CE separation capillary with hydrofluoric acid (HF) which renders the end of the fused-silica capillary porous . The capillary is placed in a stainless steel ESI needle. Co-axially a conductive liquid is delivered to the outside of the porous end which makes a hydraulic electrical contact between the ESI needle and the CE separation BGE. This essential concept has been implemented by Beckman Coulter in a prototype system in 2010 and brought to market very recently (now Sciex Separations, CESI 8000 High Performance Separation-ESI Module, figure taken from the website).